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Histology of the Larynx

*Larynx*

For medical students2 min readUpdated 2026-10-10

The larynx is a hollow tubular organ of the respiratory system connecting the pharynx to the trachea, resembling an hourglass in shape. Histologically, the larynx is notable for the complete absence of a submucosa and the complex, multi-component structure of its vocal apparatus.

LayersThe wall consists of three layers. The submucosa is entirely absent.
Vocal foldsTrue vocal folds contain skeletal muscle tissue, whereas false vocal folds contain smooth muscle.
Cartilaginous frameworkFormed by a combination of hyaline and elastic cartilage tissues.

Topography and Anatomical Regions

Superiorly, the larynx communicates with the pharynx, and inferiorly it transitions into the trachea. The internal cavity of the organ is narrowed in the center (resembling an hourglass), which divides the larynx topographically and functionally into three regions:

  1. Vestibule of the larynx (Supraglottic region). An expanded upper part leading from the laryngeal inlet to the constriction.
  2. Middle region (Glottis). A narrowed area where the vocal apparatus is located.
  3. Infraglottic cavity (Subglottic region). The expanded lower part of the organ that smoothly transitions into the trachea.

General Plan of the Wall Structure

Similar to the nasal cavity, the wall of the larynx lacks a submucosa. The wall is formed by three layers:

Fibro-Muscular-Cartilaginous Layer: The Framework of the Organ

This layer determines the shape and rigidity of the larynx. It consists of three interrelated tissue components:

Vocal Apparatus

The vocal apparatus is located in the narrowed middle region of the larynx. Its basis consists of two pairs of folds and the recesses between them:

  1. Vestibular folds (False vocal cords). The superior pair of folds. They are called "false" because their core lacks skeletal muscle tissue (containing only smooth myocytes). Consequently, they cannot alter the width of the rima glottidis and do not participate in phonation.
  2. Vocal folds (True vocal cords). The inferior pair of folds. Their core contains vocal ligaments and the vocalis muscle, formed by striated skeletal muscle. They actively participate in sound production.
  3. Laryngeal ventricles. Recesses located between the vestibular and vocal folds. Sometimes they extend superiorly to form blind appendices of varying lengths.

Mnemonic

Remember the layers of the larynx with the rule "M-F-A": Mucosa, Fibro-muscular-cartilaginous, Adventitia. Note that the submucosa is entirely absent!

Frequently asked questions

Where are the laryngeal glands located and how are they structured?

The laryngeal glands are located in the lamina propria of the mucosa, as mixed seromucous glands are described within this layer.

Characteristics of the glandular apparatus:

  • Type of secretion — seromucous (mixed) glands.
  • Surroundings — the lamina propria is formed by loose connective tissue with a high content of elastic fibers.
  • Submucosa is absent in the laryngeal wall.
Why are the vestibular folds of the larynx called "false"?

Their core lacks skeletal muscle tissue. Therefore, they do not participate in changing the width of the rima glottidis or in voice production.

Which laryngeal cartilages are composed of hyaline tissue and which are elastic?

Large cartilages (thyroid and cricoid) are formed by hyaline cartilage tissue. The epiglottis and smaller cartilages (cuneiform, corniculate) consist of elastic cartilage tissue.

Is there a submucosa in the larynx?

No, the submucosa in the laryngeal wall is completely absent, making it similar to the histological structure of the nasal cavity.

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