Sechenov School
Home › Histology › Seminal Vesicles

Seminal Vesicles

Vesiculae seminales

For medical students2 min readUpdated 2026-10-10

Seminal vesicles are paired accessory glands of the male reproductive system, represented by hollow secretory organs. They produce the fluid portion of semen, which is rich in specific proteins and energy substrates for spermatozoa.

LocationPosterior to the urinary bladder, near its base
SizeAbout 5 cm when coiled (10–15 cm when uncoiled)
EpitheliumSimple columnar
SecretionContains fructose, prostaglandins, and seminogelin

Role in the Accessory Gland System

In male reproductive system anatomy, three main groups of accessory glands contribute to the formation of the ejaculate:

  1. Paired seminal vesicles (vesiculae seminales).
  2. Unpaired prostate gland (prostate).
  3. Paired bulbourethral glands (Cowper's glands).

Anatomy and Duct System

Topographically, the organ is located strictly posterior to the urinary bladder, adjacent to its base. Macroscopically, the seminal vesicle is a highly coiled tube with a narrowed end. Due to its tortuosity in its natural state, the organ reaches a length of about 5 cm. However, if this tube is isolated and fully straightened, its length ranges from 10 to 15 cm.

The secretion drainage system is arranged as follows: the narrowed end of the seminal vesicle merges with the terminal part of the ductus deferens. This fusion forms a single ejaculatory duct. This duct then travels inward, passes through the substance of the prostate gland, and opens directly into the urethra.

Histological Structure of the Wall

At the microscopic level, the wall of the seminal vesicle consists of three well-defined layers:

Functional Significance

The primary role of the seminal vesicles as hollow glandular organs is the secretion of the fluid component of semen. Their secretion contains several components critical for reproduction:

Mnemonic

To remember the three key components of seminal vesicle secretions, use the acronym FPS: Fructose (energy/nutrition), Prostaglandins (biological activity), Seminogelin (viscosity).

Frequently asked questions

Into which specific part of the urethra does the ejaculatory duct open?

The ejaculatory duct opens into the prostatic part of the urethra.

Key features of formation and topography:

  • Ejaculatory duct (ductus ejaculatorius) — formed by the union of the terminal ductus deferens (ampulla) and the narrowed end of the seminal vesicle.
  • The duct pierces the substance of the prostate gland.
  • Its orifices open on the posterior wall of the prostatic urethra (pars prostatica), located lateral to the seminal colliculus (verumontanum).
What layers make up the wall of the seminal vesicles?

The wall consists of three coats: the mucosa (with simple columnar epithelium), the muscular layer (two layers of smooth myocytes), and the adventitia (dense connective tissue).

Why does the mucosa appear to have a "honeycomb" structure on histological slides?

This appearance is due to the mucosa forming numerous branching folds that fuse with one another, creating a complex network of chambers.

How is the ejaculatory duct formed?

It is formed by the union of the narrowed excretory end of the seminal vesicle and the terminal part of the ductus deferens.

Go deeper

More topics in Histology

Smooth Muscle TissueWhite Matter of the Spinal CordOrgan of SmellLymphatic CapillariesHistology of Tonsils and AppendixEndocrine Function of the KidneysMitochondriaMitosisChorionEmbryonic FoldingMelanocytesIntramembranous OssificationHistology →