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Antiseptics and Disinfectants: Additional Groups

For medical students2 min readUpdated 2026-10-10

In the classification of antiseptic and disinfectant agents, alongside major chemical classes, specific additional groups are distinguished. These include various synthetic compounds of mixed structure, as well as preparations derived exclusively from medicinal plant extracts.

Two groupsAdditional antiseptics are divided into synthetic and herbal preparations
SyntheticInclude agents of diverse chemical structure, such as benzydamine and hexetidine
CombinationMulti-component topical agents, such as Strepsils
Topical antibioticsGramicidin is used topically, supplementing the main group of antiseptics
HerbalBased on extracts rather than mineral raw materials or pure synthesis

Classification of Additional Groups

In pharmacology, precise classification of medicinal substances is essential. The topic of antiseptics and disinfectants is fundamental for understanding antisepsis principles. Beyond traditional chemical classes, modern nomenclature identifies so-called additional antiseptic groups.

This division is critical for properly organizing a vast pool of pharmacological agents. According to standard classification, these additional agents are broadly divided into two major and fundamentally different categories:

Understanding this structure helps medical students and clinicians navigate the diverse array of proprietary trade names and international nonproprietary names (INNs).

Synthetic Preparations of Mixed Structure

The group of synthetic antiseptics belonging to mixed and other categories brings together agents with completely different chemical structures. This category includes many well-known compounds widely used in everyday medical practice.

Key examples of synthetic compounds include:

  1. Ambazone monohydrate — a synthetic substance widely known in pharmacies under the trade name Pharyngosept.
  2. Benzydamine — the active ingredient of the popular preparation Tantum Verde.
  3. Hexetidine — the chemical basis of the medicinal product Hexoral.
  4. Picloxydine — an active component marketed under the name Vitabact.

In addition to single-component drugs, this additional group also includes combination products. A prime example of such a multi-component agent is Strepsils.

This broad category also encompasses specific antibacterial agents, specifically topical antibiotics. The sole example of such a local antibiotic mentioned in this classification section is gramicidin.

Preparations of Plant Origin

The second major additional group in the classification consists of antiseptics derived exclusively from plant sources. The fundamental difference between this group and the previous one is that all these preparations are based on medicinal plant extracts.

When answering test questions, it is crucial to understand the origin of these agents. Their source is strictly plant extracts. They are fundamentally not produced via microbiological synthesis, mined from mineral raw materials, or manufactured as pure synthetic compounds.

The armamentarium of herbal antiseptics includes the following key agents and natural raw material sources:

Mnemonic

To quickly memorize the main herbal antiseptics, use the mnemonic CEHS: Calendula, Eucalyptus, Hypericum (St. John's wort), Sanguirythrin.

Frequently asked questions

From what plant material is sanguirythrin obtained?

Sanguirythrin is obtained from Macleaya plant species (specifically Macleaya cordata and Macleaya microcarpa), utilizing the extracted mixture of alkaloid bisulfates (sanguinarine and chelerythrine). This herbal preparation is effective in mixed-etiology conditions, including purulent-inflammatory and fungal infections. Its antimicrobial spectrum covers Gram-positive and Gram-negative bacteria, as well as fungi, including Candida species and dermatophytes.

Which combination drugs belong to the additional group of antiseptics?

Combination drugs are directly classified under the additional group of antiseptics; an example is Strepsils. It contains dichlorobenzyl alcohol and amylmetacresol, exerting an antiseptic effect on Gram-positive and Gram-negative flora while relieving pain and soothing irritation.

What is the antimicrobial spectrum of chlorophyllipt?

Chlorophyllipt possesses antibacterial activity, with sources specifically noting its efficacy against staphylococcal intestinal infections. It is also indicated for cholecystitis and pyelonephritis. Additionally, chlorophyllipt stimulates tissue regeneration processes.

What is the mechanism of action of benzydamine?

While the molecular mechanism of benzydamine is not detailed, its pharmacological triad of action is well-defined. The drug exhibits the following effects:

  • Antiseptic action.
  • Anti-inflammatory action.
  • Local anesthetic action.

The spectrum of activity of benzydamine includes bacteria (including Gardnerella vaginalis), fungi, and trichomonads. It is used in dentistry, ENT practice, and gynecology.

What are plant-based antiseptic preparations strictly based on?

These preparations are based strictly on medicinal plant extracts. As emphasized in the classification, they are not produced from mineral raw materials, synthetic compounds, or microbiological synthesis products.

To which classification group does Strepsils belong?

Strepsils is classified as a combination product. In general systematics, it falls under the additional (mixed and other) groups of antiseptics.

Is gramicidin considered a standard antiseptic agent?

No, gramicidin is classified separately as a topical antibiotic. However, in educational literature, it is reviewed alongside additional antiseptic groups.

What trade names correspond to substances such as ambazone, benzydamine, and hexetidine?

Ambazone monohydrate is marketed as Pharyngosept, benzydamine is known as Tantum Verde, and hexetidine serves as the basis for Hexoral.

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