Pharmacological Action
The pharmacological profile of diosmin is attributed to its ability to protect the vascular bed. The substance exhibits pronounced angioprotective activity, helping to restore the damaged endothelium and improve hemorheological properties.
Key effects include:
- reducing blood viscosity and platelet aggregation;
- normalizing vascular wall permeability;
- decreasing fluid filtration and leukocyte diapedesis;
- general activation of microcirculation.
Indications for Use
The therapeutic scope of diosmin covers various vascular disorders and microcirculatory pathologies. The drug is prescribed for:
- chronic venous insufficiency;
- diabetic angiopathy (including retinopathy and nephropathy);
- post-thrombotic syndrome and lower extremity peripheral artery disease;
- trophic ulcers;
- prevention and treatment of thrombosis of various locations;
- ischemic stroke and vascular encephalopathy.
Contraindications and Precautions
The use of diosmin requires considering several contraindications to ensure patient safety. The drug is contraindicated in:
- hypersensitivity to the active substance;
- hemorrhagic diathesis and bleeding disorders;
- acute hemorrhagic states;
- the first trimester of pregnancy;
- breastfeeding.
Side Effects
As a rule, diosmin is well tolerated by patients. However, adverse reactions affecting various organ systems may occur during pharmacotherapy.
Potential adverse effects:
- gastrointestinal system: nausea, vomiting, diarrhea, epigastric pain;
- nervous system (rarely): headache, dizziness;
- allergic manifestations: skin rash and pruritus.