Mechanism of Action
Prenoxdiazine exerts its effect at the peripheral level by acting directly on the sensory receptors of the bronchial mucosa. The core components of its mechanism include:
- Local anesthetic effect: reduces receptor sensitivity, which prevents the triggering of the cough reflex.
- Bronchodilatory effect: relaxes the smooth muscle of the bronchi, facilitating breathing.
- Anti-inflammatory effect: dampens inflammatory processes in the airways.
Pharmacological Effects
Unlike centrally acting antitussives (e.g., codeine), prenoxdiazine does not affect the cough center in the brain. This eliminates the risk of drug dependence and respiratory center depression, making it a drug of choice when cough suppression is required without a sedative effect.
Side Effects
The most common adverse reactions include:
- Numbness of the tongue (associated with the local anesthetic action of the drug).
- Dry mouth.
- Gastrointestinal disturbances (diarrhea).
Clinical Administration
The drug is taken orally. The standard therapeutic dosage is 0.1–0.2 g per dose, administered 2–4 times daily. It is important to note that the drug lacks mucolytic or expectorant properties; therefore, it should not be combined with mucolytics without specific clinical indications.