Mechanism of Action and Pharmacological Effects
The substance exerts pronounced angioprotective and vasodilating action. Key pharmacological effects include:
- inhibition of platelet aggregation;
- improvement of microcirculation parameters;
- reduction of total peripheral vascular resistance;
- increased tissue oxygenation and improved trophic state;
- opening of collaterals and acceleration of regenerative processes.
Clinical Indications
Drugs of this group find application in various vascular pathologies:
- Chronic lower extremity artery disease (stages II–IV), including critical limb ischemia.
- Presence of trophic ulcers and marked microcirculatory disorders.
- Manifestations of Raynaud's syndrome.
- Post-operative states following vascular surgery.
Contraindications and Adverse Reactions
The use of the drug has a number of strict contraindications and can cause adverse effects.
Contraindications
- decompensated heart failure and pulmonary edema;
- recent myocardial infarction (within the first six months);
- severe cardiac arrhythmias;
- increased bleeding tendency, as well as pregnancy and lactation.
Adverse Effects
Blood pressure fluctuations, tachycardia, headaches, myalgia, arthralgia, and local reactions are possible.