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Viruses

*Vira*

For medical students2 min readUpdated 2026-10-10

Viruses are microscopic intracellular infectious agents that are obligate parasites and cannot replicate outside of living cells. Their name is derived from the Latin word virus, meaning "poison".

Virion size20–300 nm (on average about 100 times smaller than bacteria)
Genetic materialNucleic acid: either DNA or RNA
Main classification criterionType of nucleic acid (DNA or RNA viruses)
ReproductionUtilizes host cell resources and structures

General Characteristics and Metabolism

The etymology of the term comes from the Latin virus — poison. These agents are extremely small microorganisms, ranging from 20 to 300 nm in size. Compared to bacteria, they are on average about 100 times smaller.

Their primary biological feature is that they are obligate parasites. This means they are completely incapable of replication outside of living cells. They entirely lack their own protein-synthesizing systems, so they hijack the resources and cellular structures of the host organism for reproduction.

Structure of the Viral Particle

A mature viral particle is called a virion. Its architecture includes mandatory and optional elements:

Functional Components and Their Purpose

The virion structure includes specific components that ensure its viability and interaction with the organism:

Upon entering the body, these agents are recognized by the immune system as foreign objects, triggering the production of specific antibodies.

Principles of Classification

Taxonomy is based on a fundamental criterion — the type of nucleic acid contained (typically, a virus contains only one type).

Based on this feature, two main groups are distinguished:

  1. DNA-containing viruses
  2. RNA-containing viruses

The presence or absence of specific antibodies against virion components is widely used in practice for the serological diagnosis of infections.

Mnemonic

A virus is a "poison" (virus) in protein armor (capsid), taking what isn't its own (cell resources) and carrying either DNA or RNA.

Frequently asked questions

What are the functions of the viral capsid and envelope?
  • Capsid — a protein shell that protects the viral genetic material.
  • Envelope (supercapsid) — an additional outer lipid or lipoprotein membrane not present in all viruses; it is derived from modified host cell membranes. Its surface may feature glycoprotein spikes — peplomers — involved in viral attachment to cells. In the influenza virus, surface hemagglutinin ensures attachment to respiratory epithelial cells, while neuraminidase facilitates viral entry and the release of new viral particles from the cell. Viral envelope proteins possess antigenic properties and induce the production of specific antibodies. Destruction of the lipid envelope by fat solvents leads to viral inactivation.
What is a virion?

A virion is a mature viral particle possessing a full set of structural elements, including the genetic apparatus and protective coats.

What is the main criterion used to classify viruses?

The primary classification criterion is the type of nucleic acid forming the genome — DNA or RNA.

Why are viruses called obligate parasites?

Because they lack their own metabolism and protein synthesis systems, and are entirely incapable of replication outside of living cells.

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