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Nervous System and Neuron

Systema nervosum

For medical students2 min readUpdated 2026-10-10

The nervous system is the primary regulatory apparatus of the body. Working in close coordination with the endocrine system, it regulates the body's response to internal and external environmental changes. Its structural and functional baseline unit is the neuron.

Primary unitThe neuron is the main structural and functional unit of the nervous system
ConnectionsA single neuron can form up to several thousand synapses
Nerve compositionMost peripheral nerves contain both sensory and motor fibers
Signal delayImpulse transmission across a chemical synapse always involves a slight synaptic delay

General Functions of the Nervous System

The nervous system (systema nervosum) acts as a universal coordinator. It not only ensures the synchronized function of all organ systems but also enables the body to adapt appropriately to various stimuli.

Globally, its functions are divided into three sequential steps:

Neuron: Structure and Impulse Direction

The foundation of nervous tissue is the neuron, which functions with the essential metabolic and structural support of neuroglia.

Every neuron has a distinct anatomical structure:

  1. Cell body (corpus / soma) — the central metabolic region.
  2. Dendrites (dendritae) — short, highly branched receptive processes.
  3. Axon (axon, or neuritum) — the single long efferent process.

Neurons are organized into chains along which action potentials propagate. Signals always travel in a strictly unidirectional pathway: they are received by dendrites, conducted to the neuronal cell body, and then propagated along the axon toward the next target cell or tissue.

Interneuronal Contacts: Synapses

For an impulse to pass from one neuron to another, it requires a specialized junction called a synapse (synapsis). Signal transmission here is primarily chemical, mediated by signaling molecules known as neurotransmitters.

Key features of synaptic transmission include:

Classification of Neurons and the Reflex Arc

Based on their functional role, neurons are classified into three main groups:

These cells combine to form reflex arcs. The simplest reflex arc consists of three elements: a signal travels from an afferent neuron to an interneuron, and then to an efferent neuron. More complex reflex arcs incorporate numerous interneurons organized into extensive neuronal networks.

Nerves and Types of Nerve Fibers

Macroscopic nerves are essentially bundles of neuronal processes wrapped in connective tissue sheaths. The fibers within them are divided into two main functional types.

Afferent fibers:

Efferent fibers:

The vast majority of peripheral nerves are mixed nerves, containing both afferent and efferent fibers.

Division of the Nervous System

Anatomically and functionally, the nervous system is divided into several major divisions.

Based on anatomical and topographical principles:

Functionally, the nervous system is divided into the somatic nervous system (systema nervosum somaticum) and the autonomic nervous system (systema nervosum autonomicum). The autonomic nervous system is further subdivided into sympathetic and parasympathetic divisions, which exert largely antagonistic effects on visceral organs.

Mnemonic

To remember the direction of impulse conduction in a neuron, use the rule "D-T-A": Dendrite → Telo (Cell body/Soma) → Axon. Signals always travel in this exact sequence.

Frequently asked questions

How are neurons classified based on the number of processes?

Based on the number of processes arising from the cell body, neurons are categorized into four major morphological types:

  • Unipolar neurons — possessing a single process.
  • Bipolar neurons — possessing two distinct processes (one axon, one dendrite).
  • Pseudounipolar neurons — a variant of bipolar neurons where the two processes fuse close to the soma into a single stem before branching.
  • Multipolar neurons — possessing one axon and multiple dendrites.

This morphological classification underpins the structural organization of neural pathways.

What types of cells comprise the neuroglia?

Neuroglia are classified based on their anatomical location within the CNS or PNS and their embryological origin: CNS glia include:

  • Microglia — cells of mesenchymal/monocytic macrophage origin.
  • Macroglia — cells of neuroectodermal origin, including astrocytes, ependymal cells, and oligodendrocytes.

PNS glia include:

  • Satellite cells (amphicytes) — surrounding neuronal cell bodies in ganglia.
  • Schwann cells (neurolemmocytes) — forming myelin sheaths around peripheral nerve fibers.

Oligodendrocytes further differentiate into satellite oligodendrocytes near cell bodies and interfascicular oligodendrocytes that myelinate CNS axons.

Which specific neurotransmitters mediate signal transmission at synapses?

Signal transmission is mediated by primary neurotransmitters and various co-transmitters. Cholinergic synapses utilize:

  • Acetylcholine — the primary neurotransmitter.
  • Vasoactive intestinal polypeptide (VIP) — a co-transmitter.

Adrenergic and noradrenergic synapses utilize:

  • Norepinephrine — the primary sympathetic postganglionic neurotransmitter.
  • Epinephrine — released systemically by adrenal medulla chromaffin cells.
  • Dopamine — a catecholamine and co-transmitter.
  • ATP — functioning as a purinergic co-transmitter.
  • Neuropeptide Y — a neuromodulatory peptide.
  • Somatostatin — a co-transmitter.

Many central synapses store and release multiple neurotransmitters simultaneously or sequentially into the synaptic cleft.

What are the specific functional differences between the sympathetic and parasympathetic divisions?

The sympathetic and parasympathetic divisions exert largely antagonistic regulatory effects on visceral organs to maintain physiological homeostasis.

SystemEffect on Gastrointestinal TractEffect on Cardiovascular System
SympatheticInhibits peristalsis and glandular secretionIncreases heart rate (positive chronotropy), vasoconstriction
ParasympatheticStimulates peristalsis and secretionDecreases heart rate (bradycardia), vasodilation of specific vascular beds, lowers blood pressure

Balanced coordination between both systems is essential for normal visceral function.

What is the difference between dendrites and an axon?

Dendrites are typically short, highly branched processes that conduct electrical impulses toward the neuronal cell body. The axon is a single long process that conducts impulses away from the cell body to target tissues.

What structures form afferent nerve fibers?

Afferent fibers are formed by the peripheral processes (dendrites) of sensory neurons, and they terminate peripherally in specialized sensory receptors.

Where are the cell bodies of efferent (motor) neurons located?

Their cell bodies (perikarya) are located entirely within the central nervous system — specifically within the gray matter of the brain and spinal cord.

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