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Iatrogenesis

*Iatrogenia*

For medical students2 min readUpdated 2026-10-10

Iatrogenesis refers to the development of diseases or pathological complications directly caused by the actions of medical personnel during therapeutic, diagnostic, or preventive procedures.

EtymologyFrom the Greek *iatros* (physician) and *genes* (originating)
Diagnostic StatusClassified under the "underlying disease" category in autopsy reports
Core EssenceConsequences of medical interventions leading to impaired function or death
Medical ActionsSubdivided into medical errors and medical misconduct/malpractice

Concept and Origin of the Term

The word iatrogenia is derived from the Greek roots iatros (physician) and genes (arising from, produced by). In pathology, this term encompasses any adverse consequences of medical procedures—whether diagnostic, therapeutic, or preventive. The ultimate outcome of such interventions is functional impairment, disability, or death of the patient.

In the structure of an autopsy diagnosis, such conditions occupy a specific position and are always entered directly under the "underlying disease" category.

Classification of Medical Actions

When adverse outcomes occur, the actions of medical personnel are divided into two main categories:

  1. Medical error — A conscientious misjudgment by a healthcare professional while performing professional duties. The key criterion is that the individual physician could not foresee and prevent this outcome. Such situations exclude negligence, ignorance, or malicious intent.
  2. Medical misconduct (malpractice/offense) — A situation where the specialist had a realistic opportunity to foresee and prevent negative consequences but failed to do so.

Causes and Legal Status of Medical Errors

The occurrence of medical errors is driven by objective factors:

Regarding medical misconduct, its causes are most frequently negligence (breach of direct duties) or mercenary motives. Such incidents lead to severe or fatal outcomes, though the legal status and the establishment of a crime can be determined exclusively by a court of law.

Frequently asked questions

How to properly format the complete structure of an autopsy diagnosis in cases of iatrogenesis?

The provided materials do not describe the complete autopsy diagnosis structure for iatrogenic conditions. They only specify the main formatting rule: iatrogenic conditions are entered under the "underlying disease" category.

Iatrogenesis itself is defined as any adverse consequence of preventive, diagnostic, or therapeutic interventions that leads to functional impairment, disability, or death. Within diagnostic theory, these are viewed as independent diseases or pathological processes caused by the actions of medical personnel.

What specific pathological processes and complications most commonly act as iatrogenic conditions?

The provided materials list the following iatrogenic diseases, pathological processes, and complications:

  • Hemorrhagic syndromes — resulting from the use of direct and indirect anticoagulants, antiplatelet agents, and fibrinolytics.
  • Pulpitis — toxic, including iatrogenic, caused by medications and filling materials during treatment protocol violations.
  • Cystitis — hemorrhagic cystitis due to cytotoxic drugs and radiation cystitis following bladder irradiation.
  • Pericarditis — secondary iatrogenic pericarditis, as well as post-cardiac surgery or post-radiation therapy pericarditis.
  • Iatrogenic Cushing's syndrome — caused by medication administration.
  • Granulocytopenia — following radiation or cytostatic therapy, as well as treatment with toxic drugs.
  • Chylothorax and thoracic duct injuries — including iatrogenic postoperative injuries and those associated with central venous catheterization.
  • Secondary gout — during cytostatic therapy and prolonged diuretic treatment.
  • Bradyarrhythmias — may have a drug-induced iatrogenic etiology.
  • Acquired prion diseases — iatrogenic transmission route of the infectious agent is possible.
  • Acute infective endocarditis — potential iatrogenic causes include cardiac surgery and intracardiac catheterization.
  • Cardiogenic shock — among other causes, iatrogenic catheterization complications, overdose, or unwarranted administration of beta-blockers or calcium channel blockers are listed.
  • Hemoptysis and hemorrhage — possible during anticoagulant therapy.
What is classified as iatrogenesis in pathology?

Any adverse consequence of diagnostic, preventive, or therapeutic interventions by medical personnel that leads to functional impairment, disability, or death of the patient.

Where is iatrogenesis recorded in the diagnosis structure?

According to pathological anatomy guidelines, iatrogenic conditions are entered directly under the "underlying disease" category.

How does a medical error differ from medical misconduct?

An error is a conscientious misjudgment due to a lack of experience or resources that the physician could not prevent. Misconduct (malpractice) occurs due to negligence or malice when the specialist had the opportunity to avoid the consequences but neglected their duties.

Who establishes the fact of medical malpractice?

Medical malpractice has a special legal status and is established exclusively by a court of law.

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