Sechenov School
Home › Physiology › Negative Emotions and Psychosomatics

Negative Emotions and Psychosomatics

For medical students2 min readUpdated 2026-10-10

Negative emotions are not merely a matter of subjective psychological discomfort, but a powerful physiological factor capable of triggering severe pathological processes. Unresolved and prolonged negative experiences serve as the foundation for the development of the majority of psychosomatic disorders.

Two pathwaysEmotions are realized via the ascending pathway (cerebral cortex) and the descending pathway (internal organs).
AftereffectNegative emotions persist for hours and days even after the trigger is removed.
SummationRepeated bursts of negative emotions significantly increase their overall duration.
TriggerThe leading pathogenetic factor is a prolonged, insoluble conflict situation.

Medical Aspects of Emotions and Their Properties

From the perspective of normal physiology, any emotion has two main directions of realization in the body:

  1. Ascending direction. Impulses are directed to the cerebral cortex, which is outwardly manifested as higher nervous activity and subjective awareness of the experience.
  2. Descending direction. Excitation spreads to the periphery, affecting virtually all internal organs and tissues.

Negative emotions pose the greatest medical hazard. The primary pathogenic emotions are traditionally considered to be anger, despair, and fear. Their destructive potential is due to specific undesirable properties.

First, they exhibit a prolonged aftereffect. Unlike many other physiological responses, a negative emotion does not fade immediately after the cessation of the irritating factor (trigger). The emotional trace can persist for many hours or even days.

Second, negative experiences possess the capacity for summation. If a negative emotion arises repeatedly before the previous emotional trace has faded, their effects overlap, and the total duration and intensity of the excitation increase substantially.

Mechanisms of Stagnant Emotion Formation

Frequent and repeated manifestations of negative experiences lead to a dangerous neurophysiological phenomenon: the emotion transitions into a stagnant form. This state represents a stationary, persistent excitation of brain structures.

The neurophysiological basis of a stagnant emotion lies in the prolonged circulation of excitation within closed neural circuits of the limbic structures.

As a result of this prolonged impulse circulation, structural and functional changes occur:

Impact on Visceral Functions and Psychosomatic Development

Stagnant emotional excitation inevitably impacts the functioning of internal organs. The pathogenesis of these disorders unfolds as follows:

  1. Powerful streams of descending excitation originate from the limbic system. They target internal organs, primarily affecting the uncontrolled (autonomic) components of emotions.
  2. Physiological mechanisms of homeostatic self-regulation initially attempt to counteract these pathological influences.
  3. However, under prolonged and continuous pressure, resources become depleted. A predictable failure of the 'weak link' in the autonomic self-regulation system occurs.

The outcome of this breakdown is the formation of psychosomatic diseases. The most frequent manifestations include essential hypertension, cardiac arrhythmias, and peptic ulcer disease. Additionally, asthmatic attacks, severe skin disorders, sexual dysfunction, and various autoimmune conditions may arise against the background of emotional exhaustion.

The Conflict Situation as a Trigger Mechanism

The leading factor provoking the formation of a stagnant negative emotion is a conflict situation.

In physiological terms, a conflict situation is a condition in which an individual experiences a pronounced social or biological need, but completely lacks the ability to achieve the primary adaptive result required to satisfy it. Prolonged and continuous conflicts pose the greatest threat to health.

The dynamics of pathological development progress through five successive stages:

  1. Adaptive reaction. Negative emotional excitation escalates, designed to mobilize strength to overcome the arising barrier.
  2. Generalization. If the conflict remains unresolved, the excitation begins to encompass virtually the entire brain.
  3. Descending influence. Generalized excitation massively spreads to internal organs.
  4. Feedback (afferentation). Organs operating in an altered, stressed mode send escalating feedback signals back to the brain.
  5. Outcome. Excessive bottom-up impulses maintain top-down excitation, forming a pathological 'vicious circle' of emotional arousal that is extremely difficult to break without medical intervention.

Mnemonic

Stages of the pathological process (AGNOI): Adaptation ➔ Generalization ➔ Descending influence ➔ Feedback afferentation ➔ Outcome (vicious circle).

Frequently asked questions

Through which specific closed neural circuits of the limbic structures does excitation circulate during a stagnant emotion?

During stagnant negative emotions, excitation is prolonged and circulates through several closed ring interconnections of limbic structures.

The system includes the following pathways:

  • The Papez circuit (large hippocampal loop) — the pathway passes through the mamillary bodies, thalamus, hippocampus, entorhinal cortex, septal nuclei, and returns to the mamillary bodies of the hypothalamus.
  • The septo-amygdaloid pathway — connects the septum, diagonal band, amygdala, stria terminalis, and returns to the septum.
  • The septo-hippocampal circuit — impulses travel through the septum, supracallosal striae, hippocampus, fornix, and return to the septum.
Why do some emotions cause illness while others do not?

Pathogenic emotions are typically prolonged negative emotions (anger, despair, fear) because they are capable of summation, possess a prolonged aftereffect, and can transition into a stagnant form.

What is a stagnant emotion from a neurophysiological perspective?

It is a persistent state of brain excitation in which impulses circulate continuously through closed circuits of the limbic system, altering neuronal sensitivity to neurotransmitters and peptides.

How exactly does stress transition into physical illness?

Descending signals from the brain overload internal organs. When homeostatic self-regulation mechanisms fail, the 'weak link' breaks (e.g., blood pressure rises or a GI ulcer develops).

What constitutes a conflict situation in physiology?

It is a situation in which a person has a strong drive or need, but possesses no means or opportunity to achieve the outcome required to satisfy it.

Go deeper

More topics in Physiology

Respiratory Functional SystemPhysiology of Behavior and LearningPlethysmographyEnergy BalanceFormation of Voluntary MovementsLong-Term MemoryAutonomic Reflexes and Reflex ArcsLeukocytesParameters of Cardiac Pumping FunctionPancreatic Hormones and Metabolic RegulationSmall Intestine: Secretion and MotilityRespiration at Low Atmospheric PressurePhysiology →