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Properties of Living Organisms. Principles of Physiological Regulation

For medical students2 min readUpdated 2026-10-10

Living organisms are inextricably embedded in the space-time continuum and fully adapted to Earth's physical conditions. Basic physiological properties, such as irritability, memory, and the ability to anticipate events, allow biological systems to survive, segregate from non-living matter, and actively influence the environment.

ChronologyLife originated ~0.5–1 billion years ago, adapting to Earth's pre-existing physical environment.
BarrierThe universal mechanism for isolating living matter from non-living matter is cellular phospholipid membranes.
IrritabilityDuring evolution, this basic property transformed into excitability.
AnticipationThe organism is capable of preparing for an event before it actually occurs.

Environmental Interaction and Physiological Isolation

The habitat represents a strictly organized space-time continuum. On Earth, it is defined by gravity, the atmosphere, temperatures, and the electromagnetic field. External phenomena are divided into episodic events (e.g., earthquakes) and periodically repeating events (alternation of day and night, seasons). Regular rhythmic influences play a key role in shaping biological properties across generations.

Despite their close connection with the environment, living organisms are isolated from non-living nature. This boundary is maintained by phospholipid membranes. Their structure is universal: the membranes of a human nerve cell and a sea urchin egg are structured almost identically. The emergence of such structures allowed living forms to separate from the primordial aqueous environment, complicate their internal organization, and begin actively influencing the surrounding world.

Stimuli and Types of Irritability

Any environmental factors acting on cell membranes are called stimuli. They can be physical (temperature, mechanical), chemical (hormones, acids), physico-chemical (pH changes, osmotic shifts), biological (viruses), and informational (speech, emotions).

The ability to respond to these factors by altering membrane and protoplasm structure is called irritability. There are two main types:

  1. Nonspecific (trigger) irritability. Independent of the stimulus type. The stimulus acts as a trigger that initiates internal membrane processes, bringing molecules to a threshold state.
  2. Specific (selective) irritability. Manifests in response to biologically active substances (ligands). Protein receptors on the cell membrane interact with stimuli via a lock-and-key mechanism, triggering a cascade of intracellular reactions. This selectivity is also regulated by the size of ion channels.

Memory and Anticipatory Reflection of Reality

The fixation of molecular changes resulting from stimuli is ensured by the universal genetic apparatus—the basis of biological memory. It is most vividly formed during repetitive exposures or single, strong emotional stimuli.

Based on memory, Academician P.K. Anokhin formulated the concept of anticipatory reflection of reality. This is the fundamental ability of an organism to foresee the course of external events and react to them faster than they actually occur.

The process is formed in three stages:

Mnemonic

To memorize the five groups of stimuli, use the acronym PIPhPB: Physical, Informational, Physico-chemical, Chemical (Ph in Russian/transliteration context can be adapted as Biological, Physical, Informational, Chemical, Physico-chemical). Note: Keep standard English mnemonic frameworks in mind if needed, but the original Russian mnemonic translates structurally to Physical, Informational, Chemical, Physico-chemical, Biological.

Frequently asked questions

Which body tissues are classified as excitable tissues?

Excitable body tissues include three types of tissue: nervous, muscular, and glandular (secretory).

  • Nervous tissue — possesses the highest excitability; its specific function is the generation of a nerve impulse (origination and conduction of excitation).
  • Muscular tissue — possesses lower excitability; the specific sign of its excitation is contraction (decrease in muscle fiber length or change in tension).
  • Glandular tissue — has the lowest excitability; the specific response is secretion (release of a secretion).
What are the main principles of physiological regulation of body functions?

The main principles of physiological regulation are the maintenance of homeostasis by functional systems, the use of feedback (the reflex ring), and the integration of different signal transmission pathways. Regulation of functions is carried out in three ways:

  • Nervous regulation — is implemented rapidly and acts for a short duration via the nervous system.
  • Humoral regulation — proceeds relatively slowly through substances (hormones, cytokines, mediators) circulating in body fluids.
  • Neurohumoral regulation — the primary form of regulation, combining rapid nervous and prolonged humoral influences on organs and nerve centers.
What is the principle of negative feedback in physiology?

The principle of negative feedback in biochemical self-regulation is that when the final product of a reaction chain accumulates to a certain level, it inhibits the further progression of the process. The final product N acts as an allosteric inhibitor of a key enzyme. The accumulating product can bind to the enzyme, alter its conformation, and convert it into an inactive state; inhibition of the reaction chain starts from the rate-limiting step, and product production ceases until its concentration drops.

What is the difference between trigger and selective irritability?

Trigger irritability does not depend on the quality of the stimulus—it merely launches the reaction like a trigger. Selective irritability works strictly specifically via a lock-and-key mechanism through protein receptors.

What is the chemical continuum in Anokhin's theory?

It is an inseparable chain of molecular changes formed within the organism that arises upon repeated external stimuli, allowing the organism to react to them in anticipation.

How is irritability related to excitability?

Irritability is the primary, basic property of living matter to respond to stimuli. During evolution, in specialized tissues (nervous and muscular), it transformed into excitability.

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