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Corpus Callosum and Fornix

Corpus callosum et fornix

For medical students2 min readUpdated 2026-10-10

The corpus callosum is the largest commissure of the telencephalon, primarily responsible for connecting the cortex of both cerebral hemispheres. Closely associated with it, the fornix is a major white matter tract and a core component of the limbic system (rhinencephalon).

Largest CommissureThe corpus callosum is the most massive interhemispheric fiber bundle connecting the cerebral hemispheres.
Indusium GriseumThe superior surface of the corpus callosum is covered by a very thin layer of gray matter.
Fornix ContinuityThe crura of the fornix continue directly into the fimbria of the hippocampus.

Anatomy of the Corpus Callosum

When studying the brain, the corpus callosum (corpus callosum) is a central landmark. As the largest commissure of the telencephalon, its fibers cross between the hemispheres, ensuring functional and anatomical integration.

Anatomically, the corpus callosum is divided into four sequential parts:

The fibers composing the corpus callosum radiate outward into the white matter of each hemisphere. Anteriorly, they form the forceps minor (forceps frontalis), connecting the frontal lobes. Posteriorly, they form the forceps major (forceps occipitalis), connecting the occipital lobes.

The superior surface of the corpus callosum is covered by the indusium griseum (indusium griseum), a delicate vestigial layer of gray matter. Within this gray layer, anatomists identify the medial and lateral longitudinal striae (striae longitudinales mediales and striae longitudinales laterales).

Fornix: White Matter Tracts

The fornix (fornix) is a massive, arching white matter tract composed of longitudinally running nerve fibers. Topographically classified as telencephalic white matter, it functions as part of the limbic system.

For descriptive purposes, the fornix is divided into three main parts:

  1. Columns of the fornix (columnae fornicis) — curving anteriorly and inferiorly;
  2. Body of the fornix (corpus fornicis) — the central, elevated portion;
  3. Crura of the fornix (crura fornicis) — diverging posteriorly and inferiorly.

A transverse interhemispheric connection between the right and left fornices is known as the commissure of the fornix (commissura fornicis), which enables communication between symmetrical structures. Inferiorly, the crura continue seamlessly into the fimbria of the hippocampus (fimbria hippocampi).

Hippocampus and Its Topography

The hippocampus (hippocampus) is a prominent curved elevation of gray matter approximately 3 centimeters long, located within the floor of the inferior horn of the lateral ventricle.

The ventricular surface of the hippocampus is covered by a thin layer of white matter termed the alveus of the hippocampus (alveus hippocampi).

Relationships with Other Structures

Medial to the hippocampus lies the fimbria of the hippocampus (fimbria hippocampi), visualized as a prominent white band. As noted earlier, this fimbria is the direct anatomical continuation of the crus of the fornix (crus fornicis).

The anterior end of the hippocampus expands and curves to form the uncus (uncus), which is structurally continuous with the parahippocampal gyrus.

Frequently asked questions

Where do the columns of the fornix terminate?

The columns of the fornix (columnae fornicis) terminate in the mamillary bodies at the base of the brain. Descending through the gray matter of the hypothalamus on each side, they form the anterior boundaries of the interventricular foramina connecting the lateral and third ventricles.

What structures are connected by the commissure of the fornix?

The commissure of the fornix connects the right and left crura of the fornix via transverse nerve fibers. It is located just below the splenium of the corpus callosum.

What pathways run within the fimbria of the hippocampus?

The fimbria of the hippocampus (fimbria hippocampi) contains efferent nerve pathways, including:

  • Fibers from hippocampal neurons — converging on its ventricular surface as the alveus, which continues into the fimbria.
  • Efferent fibers from the subiculum — also contributing to the fimbria.

From here, fibers continue into the crus of the fornix (crus fornicis) and the fornix proper, serving as the main efferent output tract of the hippocampus.

What are the anatomical parts of the corpus callosum?

The corpus callosum consists of the rostrum, genu, body (truncus), and the thickened posterior end known as the splenium.

What are the forceps frontalis and forceps occipitalis?

These are fiber bundles of the corpus callosum radiating into the hemispheres: the forceps minor (frontalis) anteriorly and forceps major (occipitalis) posteriorly.

Where is the hippocampus located?

The hippocampus is a curved eminence about 3 cm long that forms a prominent bulge in the floor of the inferior horn of the lateral ventricle.

How are the crura of the fornix related to the hippocampus?

The crura of the fornix (crura fornicis) extend inferiorly and continue as a white band called the fimbria of the hippocampus (fimbria hippocampi), positioned medial to the hippocampus.

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