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Small Intestine

Intestinum tenue

For medical students2 min readUpdated 2026-10-10

The small intestine (intestinum tenue) is a long, tubular organ of the digestive system located between the pylorus of the stomach and the beginning of the large intestine. It is the primary site for the digestion of food and the absorption of nutrients.

LengthUp to 5 meters in adults
Diameter4–6 cm proximally, decreasing to 2.5–3 cm distally
PartsDuodenum, jejunum, and ileum
PeritoneumCovered intraperitoneally, except for the duodenum

General Characteristics and Parts

The small intestine begins directly at the pylorus of the stomach and extends to the junction with the large intestine. The total length of the organ reaches 5 meters, while the lumen of the intestinal tube gradually narrows: from 4–6 cm in the proximal parts to 2.5–3 cm near the distal end.

Anatomically, the small intestine is divided into three consecutive parts:

Most of the organ has its own mesentery (mesenterium) and is covered by the peritoneum on all sides. The only exception is the duodenum, which lies primarily retroperitoneally (behind the peritoneum).

Mesenteric Part of the Small Intestine

The mesenteric part (pars mesenterica intestini tenuis) includes the jejunum and ileum. It occupies the lower abdominal cavity, inferior to the transverse mesocolon.

This section begins at the duodenojejunal flexure (flexura duodenojejunalis), which is located to the left of the body of the 2nd lumbar vertebra. The mesenteric part ends in the right iliac fossa at the level of the 4th lumbar vertebra, where it transitions into the large intestine. The loops lie intraperitoneally and possess significant mobility due to the mesentery. Two borders are distinguished on the intestine: the mesenteric border (attachment site) and the free antimesenteric border.

The mesenteric part consists of two segments:

  1. Jejunum (jejunum) — makes up the proximal ⅔ of its length. Its loops lie mainly in the upper and left regions of the abdominal cavity. The initial diameter is 4.8–5.0 cm.
  2. Ileum (ileum) — occupies the distal ⅓. Its loops descend into the lower and right regions, reaching the pelvic cavity. The diameter of the distal segment narrows to 2.7–3.0 cm.

It is important to note that there is no distinct anatomical or histological boundary between the jejunum and the ileum.

Structure of the Intestinal Wall

The wall of the mesenteric part of the small intestine has a classic layered structure consisting of three tunics:

The relief of the mucous membrane is formed by circular folds (plicae circulares), intestinal villi (villi intestinales), and crypts (glandulae intestinales). The total number of folds ranges from 500 to 1200. They are most prominent in the jejunum, while their height and number noticeably decrease toward the ileum. Villi in the mesenteric part are shorter and thinner than in the duodenum, and their density also decreases in the distal direction.

The submucosa (tela submucosa) contains solitary lymphoid nodules (noduli lymphoidei solitarii). A specific feature of the ileum is the presence of aggregated lymphoid follicles — Peyer's patches (noduli lymphoidei aggregati).

Transition to the Large Intestine

The small intestine ends where the ileum empties into the cecum. This junction is called the ileal orifice (ostium ileale).

The orifice is surrounded by prominent folds of the mucous membrane that form a specialized ileocecal valve apparatus. It performs a crucial valve function, allowing chyme to pass in one direction (into the large intestine) while preventing backflow.

Mnemonic

The parts of the small intestine can be easily remembered as Don't Jump In: Duodenum, Jejunum, Ileum.

Frequently asked questions

Where is the border between the jejunum and the ileum?

There is no distinct anatomical boundary between them. Conventionally, the proximal ⅔ of the mesenteric part is considered the jejunum, and the distal ⅓ is the ileum.

How does the mucosa change along the mesenteric part?

In the proximal segments (jejunum), circular folds and villi are more numerous and taller. Distally (toward the ileum), their number and height decrease, while large aggregated lymphoid nodules appear in the submucosa.

How is the small intestine covered by the peritoneum?

The duodenum lies primarily retroperitoneally. The jejunum and ileum are covered by the peritoneum on all sides (intraperitoneally) and possess a mesentery.

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