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Alterations of Consciousness

For medical students2 min readUpdated 2026-10-10

Alterations of consciousness represent a group of pathological conditions accompanied by impaired perception of the environment and the self. In emergency medicine, assessing the level of consciousness is an absolute key criterion for determining the severity of a patient's condition.

Two groupsAll disorders are divided into quantitative depression and qualitative alterations of consciousness.
Stupor vs. ComaUnlike coma, stupor preserves reflexes and reactions to strong stimuli.
DeliriumThe patient actively participates in hallucinations: attacks, escapes, or holds conversations.
Twilight stateCharacterized by a sudden onset and equally abrupt termination followed by amnesia.

Classification of Disorders

Assessment of the level of consciousness is a crucial stage of diagnosis. Patient management tactics depend entirely on how accurately the physician characterizes these disturbances. According to the generally accepted approach, all disorders are broadly divided into two major categories:

  1. Depression of consciousness (quantitative decrease). This group sequentially includes obtundation, stupor, and coma.
  2. Alteration of consciousness (qualitative or productive disorders). These include delirium, amentia, and the twilight state.

Productive Forms (Alterations of Consciousness)

Qualitative disorders always develop against the background of a wakeful patient. Their main characteristic involves a disorder of higher mental functions, resulting in a profoundly altered perception of both the environment and the self.

Unproductive Forms (Depression of Consciousness)

In contrast to productive forms, depression states are characterized by a pronounced deficit of mental activity. The clinical picture is built on a classic triad: decreased level of wakefulness, depression of intellectual functions, and a sharp drop in motor activity.

Mnemonic

To quickly memorize the clinical triad of consciousness depression, use the "Three Ds" rule: Decreased wakefulness, Depression of intellect, Diminished movement.

Frequently asked questions

Which scale is used in emergency medicine to quantitatively assess the level of consciousness depression?

According to sources, quantitative assessment of the level of consciousness/coma is performed using the Glasgow Coma Scale (GCS).

The score consists of the sum of points across 3 parameters: eye opening, motor responses, and verbal responses. Additionally, sources mention the FOUR (Full Outline of UnResponsiveness) scale for assessing the level of consciousness.

What clinical stages (severity degrees) of coma are distinguished?

Sources describe only the stages of hepatic coma caused by the onset of cerebral edema and swelling:

  • Initial/shallow coma (Coma I) — characterized by loss of consciousness with preserved basic brainstem and spinal reflexes, reaction to severe pain, and swallowing.
  • Deep coma (Coma II) — characterized by total depression of CNS functions. Absolute loss of consciousness, absence of reactions to stimuli, complete areflexia, and sphincter paralysis are observed.
What types of delirium exist depending on etiology?

Sources do not provide a separate classification of delirium types by etiology. It is noted that delirium syndrome is a nonspecific exogenous-type reaction, which can be caused by:

  • alcohol withdrawal syndrome;
  • vascular diseases;
  • infections;
  • intoxications.

Additionally, alcohol delirium and infectious delirium are explicitly mentioned in the sources.

What is the main difference between stupor and coma?

The key differential sign is the preservation of reflexes in stupor. The patient reacts to severe pain, light, or sound with groaning and facial expressions, whereas in coma, consciousness and reflexes are completely lost.

What is somnolence, and in what condition does it occur?

Somnolence is pathological excessive sleepiness. It is one of the characteristic clinical manifestations of obtundation, alongside hypokinesia and confusion.

Does the patient remember what they did during a twilight state or amentia?

No, after recovering from these states (upon recovery or the end of a seizure), the patient exhibits complete amnesia for all events that occurred.

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