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Emotional Stress

For medical students2 min readUpdated 2026-10-10

Emotional stress is a state of physiological and psychological strain resulting from prolonged and continuous conflict situations. In early stages, it helps the body adapt, but prolonged chronicity disrupts self-regulation mechanisms and leads to pathology.

Stress TargetThe cardiovascular system reacts to emotional stress faster than any other system
MediatorsEuphoriant oligopeptides, substance P, prolactin, beta-endorphin
PathogenesisProlonged stimulation of negative emotion-generating centers in the hypothalamus
ProtectionDosed physical exercise, positive emotions, antioxidants

Stages and Biological Role

Emotional stress goes through two main stages:

  1. Adaptive stage. At the onset of conflict, stress plays a positive role. It mobilizes the body's resources so a person or animal can overcome or avoid the problem.
  2. Pathogenic stage. If the conflict lasts a long time, seems hopeless, or is accompanied by acute affects, stress transitions into a continuous form. As a result, the self-regulation mechanisms of functional systems break down, leading to disease.

Effects on the Cardiovascular System

Cardiovascular functions respond to stressors first. Resistance to such loads is individual: some organisms are predisposed to cardiovascular pathologies, while others are resistant. Interestingly, in individuals resistant to cardiac problems, stress often "hits" other organs, for example, causing gastric ulcers.

In predisposed individuals, prolonged irritation of negative hypothalamic zones leads to arterial hypertension. First, a transitory phase occurs (competition between pressor and depressor mechanisms), followed by a stable phase (mechanisms that raise blood pressure dominate), which can end in organic damage, up to myocardial infarction.

The Role of Movement and the Concept of "Unexpressed Emotions"

Emotions are closely linked to movement (flight, pursuit). According to W. Cannon, emotional arousal triggers the sympathoadrenal system, raising blood pressure and preparing muscles for action via catecholamines.

When muscular work begins, blood vessels in the muscles dilate, reducing peripheral resistance and compensating for the blood pressure spike. However, if immobilization occurs or a situation of "unexpressed emotions" arises (according to G.F. Lang), sympathetic activation raises blood pressure, but due to a lack of movement, compensatory vascular and baroreceptor mechanisms are not engaged. The result is chronically elevated blood pressure.

Stress Immunity and Prevention

Stress resistance can be actively enhanced. Contributing factors include:

Frequently asked questions

What diseases may develop during stress in individuals resistant to cardiovascular pathologies?

In individuals resistant to cardiovascular pathologies undergoing emotional stress, disturbances in other functions are frequently observed, notably the development of gastric ulcers.

Which brain structures, besides the hypothalamus, are involved in generating emotional stress?

Structures of the limbic system are involved in forming emotional states. Key structures include:

  • Septum (Septum) — connected to pleasure centers.
  • Amygdala (Corpus amygdaloideum) — plays a role in the formation of fear and aggression.
  • Hippocampus (Hippocampus) — responsible for the emotional coloring of memory.
  • Cingulate gyrus (Gyrus cinguli) — participates in regulating behavior and autonomic functions.
What are the stages of the General Adaptation Syndrome according to H. Selye?

By analogy with the general adaptation syndrome, three stages of the stress reaction are distinguished:

  1. Alarm reaction.
  2. Stage of resistance.
  3. Stage of exhaustion.

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