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Respiration at High Atmospheric Pressure

For medical students2 min readUpdated 2026-10-10

During diving and caisson operations, the human body is exposed to extremely high pressures, fundamentally altering the physiology of respiration. Safe deep-sea operations require specialized gas mixtures and strict adherence to prolonged decompression schedules.

Pressure GradientWhen diving underwater, ambient pressure increases by 1 atmosphere for every 10 meters of depth.
SolubilityAt depths exceeding 100 meters, the amount of nitrogen dissolved in the blood increases sharply.
LimitationBreathing pure oxygen is safe only at depths of up to 20 meters.
DecompressionReturning to the surface after one hour of work at 160 meters requires 3 days in a hyperbaric chamber.

Physical Principles of Diving

The environment in which diving and caisson operations are conducted dictates specific physical laws. As depth increases, the pressure of the water column rises uniformly: every 10 meters of depth adds 1 atmosphere. For example, at a depth of 90 meters, the external environmental pressure on the human body reaches an impressive 10 atmospheres.

Under these conditions, a person cannot physically breathe air at normal atmospheric pressure. Air or another breathing gas mixture must be delivered at a pressure that strictly matches the diver's current depth.

Effect of Gases and the Problem of Solubility

Pressure changes directly affect how gases interact with body fluids. When descending to great depths (exceeding 100 meters, corresponding to a pressure of over 10 atmospheres), a serious physiological problem arises: the amount of gases dissolved in the blood increases sharply.

This primarily involves oxygen and nitrogen. Excessive dissolution of nitrogen in the blood leads to severe consequences—so-called nitrogen narcosis—rendering standard air unsuitable for deep-water operations.

Artificial Gas Mixtures

To avoid nitrogen narcosis and ensure adequate breathing at great depths, specialized helium-oxygen mixtures (heliox) are used in physiology and diving practice.

The use of pure oxygen for underwater breathing is strictly limited. This practice is possible exclusively at shallow depths—up to 20 meters. Descending deeper causes the pure gas to exhibit pronounced toxic effects, clinically manifesting as severe muscle convulsions.

Decompression Rules

The process of returning a diver to the surface requires no less attention than the descent itself. The body needs a specific, strictly calculated transition regimen from high pressure to normal atmospheric pressure—decompression.

This process takes significant time to allow dissolved gases to safely leave the body without forming bubbles. A telling example: if a specialist spends just 1 hour working at a depth of 160 meters, the return journey to the surface, including decompression in a specialized hyperbaric chamber, takes 3 days.

Frequently asked questions

What is the pathogenesis of nitrogen narcosis during deep-water dives?

The pathogenesis of nitrogen narcosis during deep dives is related to the body's saturation with nitrogen under hyperbaric conditions. At great depths (>100 m, >10 atm), the amount of nitrogen dissolved in the blood increases sharply because gas solubility rises with pressure.

Key aspects of pathogenesis:

  • Nitrogen accumulation: nitrogen is an indifferent gas and is not metabolized by tissues during life processes.
  • Nitrogen saturation during descent induces a narcotic effect often described as "rapture of the deep".
What symptoms and syndromes manifest the toxic effects of pure oxygen at depths greater than 20 meters?

The toxic effect of pure oxygen at depths greater than 20 m manifests as muscle convulsions. The provided materials also indicate that oxygen toxicity can manifest as three pathological states—separately, sequentially, or in combination. Detailed symptoms and names of these states are not disclosed in the referenced sources.

What is the mechanism of gas bubble formation in the blood when decompression schedules are violated?

The mechanism of gas bubble formation is driven by blood gases (primarily nitrogen) transitioning into a gaseous state due to a sharp drop in barometric pressure.

During rapid ascent (decompression violation), the following occurs:

  • Excess dissolved gas does not have time to be safely eliminated via the lungs.
  • Nitrogen is retained in tissues, especially adipose tissue and cerebral white matter.
  • Gas solubility drops, forming bubbles (gas emboli) directly in the blood and tissues, leading to vascular occlusion.
How rapidly does pressure increase when diving underwater?

Ambient pressure increases by 1 atmosphere for every 10 meters of depth. For example, at a depth of 90 meters, it is approximately 10 atmospheres.

Why can normal air not be used at depths exceeding 100 meters?

At pressures exceeding 10 atmospheres, gas solubility in the blood increases sharply. Excess dissolved nitrogen causes severe nitrogen narcosis.

At what depths is breathing pure oxygen permissible?

Breathing pure oxygen is safe only at depths up to 20 meters. At greater depths, it exerts a toxic effect, causing muscle convulsions.

Why is helium added to breathing mixtures?

Helium is used for deep dives because it barely dissolves in the blood. This completely prevents the risk of nitrogen narcosis.

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